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CIMIT Programs
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INTEGRATED CLINICAL ENVIRONMENTS: - Clinical Systems Innovation
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NEUROHEALTH: - Neurotechnology
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Biomaterials & Tissue Engineering
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- Global Health Initiative
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- Optical Diagnostics
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HELPING SOLVE ORGAN SHORTAGES THROUGH THE CREATION OF "LIVING REPLACEMENT STRUCTURES"
Nearly one hundred thousand Americans are waiting for a life-saving organ transplant. Thirty thousand patients a year need a new kidney, and while treatments like dialysis can buy time, on average, one in four die before receiving a transplant. This severe organ shortage could be mitigated if a viable substitute for human tissue could be found.
Tissue engineering is a complex challenge. An interdisciplinary field, innovations in tissue engineering seek to apply the principles of engineering and life sciences in the pursuit of biological substitutes that restore, maintain, or improve tissue function.
CIMIT’s Biomaterials & Tissue Engineering Program is working to create “living replacement structures” for organs, areas of tissue, and neural repair.
- Projects
- Publications
- Forum/Events
- In The News
FY 2011 - 2008 Biomaterials & Tissue Engineering Projects |
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| Year | PRINCIPAL INVESTIGATOR | INSTITUTION | PROJECT TITLE | |
| 2011 | Colleen Channick | Massachusetts General Hospital | Creation of Amino Alcohol-Based Poly(ester amide) Elastomer Bioabsorbable Airway Stent | |
| 2010 - 2009 | Yolonda Colson, MD, PhD | Brigham and Women’s Hospital | Expansile Nanoparticles for Tumor-Targeted Drug Delivery to Prevent Lymph Node Metastases in Breast Cancer | |
| 2010 | Robert Redmond, PhD | Massachusetts General Hospital | A photo-activated nanofiber graft material for enhanced tendon repair | |
| 2009 | David Kaplan, PhD | Tufts University | A Rapid Disposable Device for Early Detection of Sepsis | |
| 2009 | Cathryn Sundback, ScD | Massachusetts General Hospital | Poly(glycerol sebacatge) film as barrier to formation of viscero-parietal peritoneal adhesions | |
| 2008 | Timothy Bhattacharyya, MD | Massachusetts General Hospital | Fracture Free Stem Inserter for Total Hip Arthroplasty: Improving Patient Safety by Enhancing Surgeon Feedback | |
| 2008 | Yolonda Colson, MD, PhD |
Brigham and Women’s Hospital | Clinical Prototype for Intraoperative Aerosolized Nanoparticle Drug Delivery | |
| 2008 | Mark Horenstein, PhD |
Boston University | Transdermal Injection of Nano Particles via Electrospray and Pulsed-Field Assist | |
| 2008 | Jeffrey Karp, PhD |
Brigham and Women’s Hospital | Intraoperative Programmable Autologous Stem Cell Therapy | |
| 2008 | Richard Lee, MD |
Brigham and Women’s Hospital | A Novel Bio-Instructive Surface for Generating Osteoblastic Cells in the OR | |
Recent Publications by CIMIT Investigators |
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| INVESTIGATOR/AUTHOR | PUBLICATION | ARTICLE | DATE |
| Borenstein, J. T., Weinberg, E. J., Orrick, B., Cheung, W., Sundback, C., Kaazempur-Mofrad, M. R., Vacanti, J. P. |
Tissue Eng. (8):1837-44 | Microfabrication of Three-Dimensional Engineered Scaffolds | 2007 |
| Ibusuki S, Halbesma GJ, Randolph MA, Redmond RW, Kochevar IE, Gill TJ | Tissue Eng. 13(8):1995-2001 | Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. | 2007 |
| Kaufman JD, Song J, Klapperich CM |
J Biomed Mater REs A. 81(3):611-23 | Nanomechanical analysis of bone tissue engineering scaffolds | 2007 |
| Mesiha, M., Zurakowski, D., Soriano, J., Nielson, J. H., Zarins, B., Murray, M. M. | Am J. Sports Medicine 35(1):81-91 | Pathologic Characteristics of the Torn Human Meniscus | 2007 |
| Murray, M. M., Spindler, K. P., Abreu, E., Muller, J. A., Nedder, A., Kelly, M., Frino, J., Zurakowski, D., Valenza, M., Snyder, B. D., Connolly, S. A. |
J. Orthop Res 25(8):81-91 | Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament | 2007 |
| Murray, M. M., Spindler, K. P., Ballard, P., Welch, T. P., Zurakowski, D., Nanney, L. B. |
J. Orthop Res 25(8):1007-17 | Enhanced Histologic Repair in a Central Wound in the Anterior Cruciate Ligament with a Collagen-Platelet-Rich Plasma Scaffold | 2007 |
| Pliquett, U. F., Weaver, J. C. | IEEE Trans Biomed Eng 54(3): 526-8, 2007 | Feasibility of an Electrode-Reservoir Device for Transdermal Drug Delivery by Noninvasive Skin Electroporation | 2007 |
| Shane Johnson, T., O’Neill, A. C., Motarjem, P. M., Amann, C., Nguyen, T., Randolph, M. A., WInograd, J. M., Kochevar, I. E., Redmond, R. W. |
J Surg Res | Photochemical Tissue Bonding: A Promising Technique for Peripheral Nerve Repair | May 31, 2007 |
| Shin, M., Abukawa, H., Troulis, M. J., Vacanti, J. P. |
J Biomed Mater Res A | Development of a Biodegradable Scaffold with Interconnected Pores by Heat Fusion and its Application to Bone Tissue Engineering | 2007 (Epub ahead of print) |
| Spencer NJ, Cotanche DA, Klapperich CM. |
Biomaterials. | Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae. | 2007 Nov 21; (Epub ahead of print) |
| Stahl JE, Vacanti JP, Gazelle S. | Int J Technol Assess Health Care Summer;23(3):331-6, | Assessing emerging technologies--the case of organ replacement technologies: volume, durability, cost. | 2007 |
Biomaterials & Tissue Engineering at the CIMIT Forum and Past Events |
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| EVENT | DATE | SPEAKERS | DETAIL |
MIT Enterprise Forum Medical Technology Innovation Series |
May 14, 2009 | Keynote: Joseph P. Vacanti, MD | Tissue Engineering: Making Regenerative Medicine A Reality |
| Forum: Stem Cell Biology and Cell-Rolling Technique | Mar 3, 2009 | David Scadden, MD: Harvard University, MGH Rohit Karnik, PhD: MIT |
• Micro-Environmental Regulation of Stem Cells • Nudging Cells Using Molecular Interactions: Towards Label-free Cell Rolling Separation |
| Forum: Bio-inspired Design and Fluidic Logic | Sep. 30, 2008 | Sangbae Kim, PhD: Harvard University Manu Prakesh, PhD: MIT |
Bio-Inspired Robot Design with Compliant Mechanism Fabrication Fluidic Logic - Merging Chemistry and Computation with Microfluidics |
| Forum: Biomimicry and Regenerative Therapeutics | Mar. 25, 2008 | Jeffrey Karp, PhD: BWH Robert Sackstein, MD, PhD: MGH, Dana-Farber Cancer Institute |
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| Forum: Nanotechnology Meets Cancer | Jan. 29, 2008 | Shiladitya Sengupta, PhD: BWH, MIT Raghu Kalluri, PhD: BIDMC |
• Nanodevices For Cancer Therapy • Tumor Microenvironment in Cancer Progression and Metastasis |
| Forum: Biomarkers: Cutting Edge Indicators to Assess Health, Monitor Disease or Determine Responsiveness to Therapy | Jan. 22, 2008 | Robert Gerszten, MD: MGH Homer Pien, PhD: MGH |
• Metabolomic Approaches for Cardiovascular
Biomarker Discovery • Imaging Biomarkers: Uses, Misuses, Successes, and Failures |
| Forum: The Quest for a Wearable Kidney and Renal Assist Devices: Will Nanotechnology Make a Difference? |
Jan. 15, 2008 | Joseph Bonventre, MD, PhD; HMS, BWH Theodore Steinman, MD; HMS, BIDMC Greg Erman, MBA; Entrepreneur, former CEO of Renalworks Medical Corp. Jeffrey Borenstein, PhD; Draper Labs, CIMIT Site Miner |
• The Impact of Chronic Kidney Disease
• Creating an Artificial Kidney |
| Forum: Leading Researchers Discuss Personalized Medicine |
Jun. 12, 2007 | Janina Longtine, MD; BWH, HMS Carolyn Mountford, D. Phil; BWH, HMS |
• Molecular Diagnostics in Personalized Cancer Care • Advanced Molecular Diagnostics and Imaging |
| Forum: Optimism about Microfabrication, Tissue-Engineered Heart Valves |
Apr. 3, 2007 | Ali Khademhosseini, PhD; BWH, HMS John Mayer, Jr., MD; HMS, CHB |
• Microengineering the Cellular Environment through the Interplay between Microfabrication and Biomaterials • Current Progress toward a Tissue Engineered Heart Valve |
Biomaterials & Tissue Engineering News |
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| ARTICLE TITLE | PUBLICATION | DATE |
| Creating the Body’s Microenvironment to Grow Artificial Organs | National Defense Magazine | Mar. 2008 |
| BioEngine: One Step Closer to Artificial Liver Device | XConomy | Sep. 20, 2007 |
| A Step Toward Tissue-Engineered Heart Structures for Children | Science Daily | Sep. 20, 2007 |
Video/Podcasts |
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Program Leaders
Jeffrey Borenstein, PhD
617-258-1686
CIMIT RESPONSIBILITIES
Co-Program Leader,
Biomaterials & Tissue
Engineering
Joseph P. Vacanti, MD
617-724-1725
CIMIT RESPONSIBILITIES
Co-Program Leader,
Biomaterials & Tissue
Engineering
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