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HELPING SOLVE ORGAN SHORTAGES THROUGH THE CREATION OF "LIVING REPLACEMENT STRUCTURES"
Nearly one hundred thousand Americans are waiting for a life-saving organ transplant. Thirty thousand patients a year need a new kidney, and while treatments like dialysis can buy time, on average, one in four die before receiving a transplant. This severe organ shortage could be mitigated if a viable substitute for human tissue could be found.
Tissue engineering is a complex challenge. An interdisciplinary field, innovations in tissue engineering seek to apply the principles of engineering and life sciences in the pursuit of biological substitutes that restore, maintain, or improve tissue function.
CIMIT’s Biomaterials & Tissue Engineering Program is working to create “living replacement structures” for organs, areas of tissue, and neural repair.
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Biomaterials & Tissue Engineering Projects |
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| PRINCIPAL INVESTIGATOR | INSTITUTION | PROJECT TITLE | |
| Timothy Bhattacharyya | Massachusetts General Hospital | Fracture Free Stem Inserter for Total Hip Arthroplasty: Improving Patient Safety by Enhancing Surgeon Feedback | |
| Paolo Bonato |
Spaulding | Development of a Markerless System for Clinical Analysis of Gait Abnormalities | |
| Joseph Bonventre |
Brigham and Women’s Hospital | Characterization and Validation of ‘Ren Alert’: A Silicon Nanowire Device for Early Diagnosis of Acute Kidney Injury | |
| Robert Brown |
Massachusetts General Hospital | Nanoparticles for MRI-Based Imaging of Axonal Transport in ALS | |
| Frederick Chen |
Brigham and Women’s Hospital | Quantitative Cardiac Restraint: Therapy for Ischemic Mitral Regurgitation | |
Yolonda Colson |
Brigham and Women’s Hospital | Drug-Eluting Closure Device for Surgical Resection Margins to Prevent Recurrence of Lung Cancer | |
| Yolonda Colson | Brigham and Women’s Hospital | Expansile Nanoparticles for Tumor-Targeted Drug Delivery to Prevent Lymph Node Metastases in Breast Cancer | |
| Mark Horenstein |
Boston University | Transdermal Injection of Nano Particles via Electrospray and Pulsed-Field Assist | |
| David Kaplan | Tufts University | A Rapid Disposable Device for Early Detection of Sepsis | |
| Jeffrey Karp |
Brigham and Women’s Hospital | Intraoperative Programmable Autologous Stem Cell Therapy | |
| Richard Lee |
Brigham and Women’s Hospital | A Novel Bio-Instructive Surgace for Generating Osteoblastic Cells in the OR | |
| Peter Masiakos |
Massachusetts General Hospital | Development of Biodegradable Elastomeric Scaffolds for Minimally Invasive Closure of Pathological Fistulas and Patient Foramina | |
| Cathryn Sundback | Massachusetts General Hospital | Poly(glycerol sebacatge) film as barrier to formation of viscero-parietal peritoneal adhesions | |
Contact Haleh Armian, CIMIT Senior Manager, Business Development
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Recent Publications by CIMIT Investigators |
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| INVESTIGATOR/AUTHOR | PUBLICATION | ARTICLE | DATE |
| Borenstein, J. T., Weinberg, E. J., Orrick, B., Cheung, W., Sundback, C., Kaazempur-Mofrad, M. R., Vacanti, J. P. |
Tissue Eng. (8):1837-44 | Microfabrication of Three-Dimensional Engineered Scaffolds | 2007 |
| Ibusuki S, Halbesma GJ, Randolph MA, Redmond RW, Kochevar IE, Gill TJ | Tissue Eng. 13(8):1995-2001 | Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. | 2007 |
| Kaufman JD, Song J, Klapperich CM |
J Biomed Mater REs A. 81(3):611-23 | Nanomechanical analysis of bone tissue engineering scaffolds | 2007 |
| Mesiha, M., Zurakowski, D., Soriano, J., Nielson, J. H., Zarins, B., Murray, M. M. | Am J. Sports Medicine 35(1):81-91 | Pathologic Characteristics of the Torn Human Meniscus | 2007 |
| Murray, M. M., Spindler, K. P., Abreu, E., Muller, J. A., Nedder, A., Kelly, M., Frino, J., Zurakowski, D., Valenza, M., Snyder, B. D., Connolly, S. A. |
J. Orthop Res 25(8):81-91 | Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament | 2007 |
| Murray, M. M., Spindler, K. P., Ballard, P., Welch, T. P., Zurakowski, D., Nanney, L. B. |
J. Orthop Res 25(8):1007-17 | Enhanced Histologic Repair in a Central Wound in the Anterior Cruciate Ligament with a Collagen-Platelet-Rich Plasma Scaffold | 2007 |
| Pliquett, U. F., Weaver, J. C. | IEEE Trans Biomed Eng 54(3): 526-8, 2007 | Feasibility of an Electrode-Reservoir Device for Transdermal Drug Delivery by Noninvasive Skin Electroporation | 2007 |
| Shane Johnson, T., O’Neill, A. C., Motarjem, P. M., Amann, C., Nguyen, T., Randolph, M. A., WInograd, J. M., Kochevar, I. E., Redmond, R. W. |
J Surg Res | Photochemical Tissue Bonding: A Promising Technique for Peripheral Nerve Repair | May 31, 2007 |
| Shin, M., Abukawa, H., Troulis, M. J., Vacanti, J. P. |
J Biomed Mater Res A | Development of a Biodegradable Scaffold with Interconnected Pores by Heat Fusion and its Application to Bone Tissue Engineering | 2007 (Epub ahead of print) |
| Spencer NJ, Cotanche DA, Klapperich CM. |
Biomaterials. | Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae. | 2007 Nov 21; (Epub ahead of print) |
| Stahl JE, Vacanti JP, Gazelle S. | Int J Technol Assess Health Care Summer;23(3):331-6, | Assessing emerging technologies--the case of organ replacement technologies: volume, durability, cost. | 2007 |
Biomaterials & Tissue Engineering at the CIMIT Forum and Past Events |
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| EVENT | DATE | SPEAKERS | DETAIL |
| Forum: Biomimicry and Regenerative Therapeutics | Mar. 25, 2008 | Jeffrey Karp, PhD: BWH Robert Sackstein, MD, PhD: MGH, Dana-Farber Cancer Institute |
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| Forum: Nanotechnology Meets Cancer | Jan. 29, 2008 | Shiladitya Sengupta, PhD: BWH, MIT Raghu Kalluri, PhD: BIDMC |
• Nanodevices For Cancer Therapy • Tumor Microenvironment in Cancer Progression and Metastasis |
| Forum: Biomarkers: Cutting Edge Indicators to Assess Health, Monitor Disease or Determine Responsiveness to Therapy | Jan. 22, 2008 | Robert Gerszten, MD: MGH Homer Pien, PhD: MGH |
• Metabolomic Approaches for Cardiovascular
Biomarker Discovery • Imaging Biomarkers: Uses, Misuses, Successes, and Failures |
| Forum: The Quest for a Wearable Kidney and Renal Assist Devices: Will Nanotechnology Make a Difference? |
Jan. 15, 2008 | Joseph Bonventre, MD, PhD; HMS, BWH Theodore Steinman, MD; HMS, BIDMC Greg Erman, MBA; Entrepreneur, former CEO of Renalworks Medical Corp. Jeffrey Borenstein, PhD; Draper Labs, CIMIT Site Miner |
• The Impact of Chronic Kidney Disease
• Creating an Artificial Kidney |
| Forum: Leading Researchers Discuss Personalized Medicine |
Jun. 12, 2007 | Janina Longtine, MD; BWH, HMS Carolyn Mountford, D. Phil; BWH, HMS |
• Molecular Diagnostics in Personalized Cancer Care • Advanced Molecular Diagnostics and Imaging |
| Forum: Optimism about Microfabrication, Tissue-Engineered Heart Valves |
Apr. 3, 2007 | Ali Khademhosseini, PhD; BWH, HMS John Mayer, Jr., MD; HMS, CHB |
• Microengineering the Cellular Environment through the Interplay between Microfabrication and Biomaterials • Current Progress toward a Tissue Engineered Heart Valve |
Biomaterials & Tissue Engineering News |
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| ARTICLE TITLE | PUBLICATION | DATE |
| Creating the Body’s Microenvironment to Grow Artificial Organs | National Defense Magazine | Mar. 2008 |
| BioEngine: One Step Closer to Artificial Liver Device | XConomy | Sep. 20, 2007 |
| A Step Toward Tissue-Engineered Heart Structures for Children | Science Daily | Sep. 20, 2007 |
Video/Podcasts |
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Program Leaders
Jeffrey Borenstein, PhD
jborenstein@draper.com
Phone: 617-258-1686
CIMIT RESPONSIBILITIES
Co-Program Leader,
Biomaterials & Tissue
Engineering
Joseph P. Vacanti, MD
jvacanti@partners.org
Phone: 617-724-1725
CIMIT RESPONSIBILITIES
Co-Program Leader,
Biomaterials & Tissue
Engineering
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