InvestigatorCIMIT FriendIndustryPatient
search
Biomaterials & Tissue Engineering

HELPING SOLVE ORGAN SHORTAGES THROUGH THE CREATION OF "LIVING REPLACEMENT STRUCTURES"

Nearly one hundred thousand Americans are waiting for a life-saving organ transplant. Thirty thousand patients a year need a new kidney, and while treatments like dialysis can buy time, on average, one in four die before receiving a transplant. This severe organ shortage could be mitigated if a viable substitute for human tissue could be found.

Tissue engineering is a complex challenge.  An interdisciplinary field, innovations in tissue engineering seek to apply the principles of engineering and life sciences in the pursuit of biological substitutes that restore, maintain, or improve tissue function.  

CIMIT’s Biomaterials & Tissue Engineering Program is working to create “living replacement structures” for organs, areas of tissue, and neural repair.

  • Projects
  • Publications
  • Forum/Events
  • In The News
Biomaterials & Tissue Engineering Projects
PRINCIPAL INVESTIGATOR INSTITUTION PROJECT TITLE
Timothy Bhattacharyya Massachusetts General Hospital Fracture Free Stem Inserter for Total Hip Arthroplasty: Improving Patient Safety by Enhancing Surgeon Feedback
Paolo Bonato

Spaulding Development of a Markerless System for Clinical Analysis of Gait Abnormalities
Joseph Bonventre

Brigham and Women’s Hospital Characterization and Validation of ‘Ren Alert’: A Silicon Nanowire Device for Early Diagnosis of Acute Kidney Injury
Robert Brown

Massachusetts General Hospital Nanoparticles for MRI-Based Imaging of Axonal Transport in ALS
Frederick Chen

Brigham and Women’s Hospital Quantitative Cardiac Restraint: Therapy for Ischemic Mitral Regurgitation

Yolonda Colson

Brigham and Women’s Hospital Drug-Eluting Closure Device for Surgical Resection Margins to Prevent Recurrence of Lung Cancer
     
Yolonda Colson Brigham and Women’s Hospital Expansile Nanoparticles for Tumor-Targeted Drug Delivery to Prevent Lymph Node Metastases in Breast Cancer
Mark Horenstein

Boston University Transdermal Injection of Nano Particles via Electrospray and Pulsed-Field Assist
David Kaplan Tufts University A Rapid Disposable Device for Early Detection of Sepsis
Jeffrey Karp


Brigham and Women’s Hospital Intraoperative Programmable Autologous Stem Cell Therapy
Richard Lee


Brigham and Women’s Hospital A Novel Bio-Instructive Surgace for Generating Osteoblastic Cells in the OR
Peter Masiakos

Massachusetts General Hospital Development of Biodegradable Elastomeric Scaffolds for Minimally Invasive Closure of Pathological Fistulas and Patient Foramina
Cathryn Sundback Massachusetts General Hospital Poly(glycerol sebacatge) film as barrier to formation of viscero-parietal peritoneal adhesions
Recent Publications by CIMIT Investigators
INVESTIGATOR/AUTHOR PUBLICATION ARTICLE DATE
Borenstein, J. T., Weinberg, E. J., Orrick, B., Cheung, W., Sundback, C., Kaazempur-Mofrad, M. R., Vacanti, J. P.
Tissue Eng. (8):1837-44 Microfabrication of Three-Dimensional Engineered Scaffolds 2007
Ibusuki S, Halbesma GJ, Randolph MA, Redmond RW, Kochevar IE, Gill TJ Tissue Eng. 13(8):1995-2001 Photochemically cross-linked collagen gels as three-dimensional scaffolds for tissue engineering. 2007
Kaufman JD, Song J, Klapperich CM
J Biomed Mater REs A. 81(3):611-23 Nanomechanical analysis of bone tissue engineering scaffolds 2007
Mesiha, M., Zurakowski, D., Soriano, J., Nielson, J. H., Zarins, B., Murray, M. M. Am J. Sports Medicine 35(1):81-91 Pathologic Characteristics of the Torn Human Meniscus 2007
Murray, M. M., Spindler, K. P., Abreu, E., Muller, J. A., Nedder, A., Kelly, M., Frino, J., Zurakowski, D., Valenza, M., Snyder, B. D., Connolly, S. A.
J. Orthop Res 25(8):81-91 Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament 2007
Murray, M. M., Spindler, K. P., Ballard, P., Welch, T. P., Zurakowski, D., Nanney, L. B.

J. Orthop Res 25(8):1007-17 Enhanced Histologic Repair in a Central Wound in the Anterior Cruciate Ligament with a Collagen-Platelet-Rich Plasma Scaffold 2007
Pliquett, U. F., Weaver, J. C. IEEE Trans Biomed Eng 54(3): 526-8, 2007 Feasibility of an Electrode-Reservoir Device for Transdermal Drug Delivery by Noninvasive Skin Electroporation 2007
Shane Johnson, T., O’Neill, A. C., Motarjem, P. M., Amann, C., Nguyen, T., Randolph, M. A., WInograd, J. M., Kochevar, I. E., Redmond, R. W.
J Surg Res Photochemical Tissue Bonding: A Promising Technique for Peripheral Nerve Repair May 31, 2007
Shin, M., Abukawa, H., Troulis, M. J., Vacanti, J. P.

J Biomed Mater Res A Development of a Biodegradable Scaffold with Interconnected Pores by Heat Fusion and its Application to Bone Tissue Engineering 2007 (Epub ahead of print)
Spencer NJ, Cotanche DA, Klapperich CM.
Biomaterials. Peptide- and collagen-based hydrogel substrates for in vitro culture of chick cochleae. 2007 Nov 21; (Epub ahead of print)
Stahl JE, Vacanti JP, Gazelle S. Int J Technol Assess Health Care Summer;23(3):331-6, Assessing emerging technologies--the case of organ replacement technologies: volume, durability, cost. 2007
Biomaterials & Tissue Engineering at the
CIMIT Forum and Past Events
EVENT DATE SPEAKERS DETAIL
Forum: Biomimicry and Regenerative Therapeutics Mar. 25, 2008

Jeffrey Karp, PhD: BWH

Robert Sackstein, MD, PhD: MGH, Dana-Farber Cancer Institute

• Biomimicry - Nature as Model, Measure and Mentor

• Steering Stem Cells to Treat Osteoporosis

Forum: Nanotechnology Meets Cancer

Jan. 29, 2008

Shiladitya Sengupta, PhD: BWH, MIT

Raghu Kalluri, PhD: BIDMC

• Nanodevices For Cancer Therapy

• Tumor Microenvironment in Cancer Progression and Metastasis

Forum: Biomarkers: Cutting Edge Indicators to Assess Health, Monitor Disease or Determine Responsiveness to Therapy Jan. 22, 2008

Robert Gerszten, MD: MGH

Homer Pien, PhD: MGH

• Metabolomic Approaches for Cardiovascular Biomarker Discovery

• Imaging Biomarkers: Uses, Misuses, Successes, and Failures

Forum: The Quest for a Wearable Kidney and Renal Assist Devices: Will Nanotechnology Make a Difference?

Jan. 15, 2008 Joseph Bonventre, MD, PhD; HMS, BWH

Theodore Steinman, MD; HMS, BIDMC

Greg Erman, MBA; Entrepreneur, former CEO of Renalworks Medical Corp.

Jeffrey Borenstein, PhD; Draper Labs, CIMIT Site Miner
• The Impact of Chronic Kidney Disease

• Creating an Artificial Kidney


• Bringing a Wearable Kidney to Market


• Engineering an Artificial Kidney

Forum: Leading Researchers Discuss Personalized Medicine

Jun. 12, 2007 Janina Longtine, MD; BWH, HMS

Carolyn Mountford, D. Phil; BWH, HMS
• Molecular Diagnostics in Personalized Cancer Care

• Advanced Molecular Diagnostics and Imaging
Forum: Optimism about Microfabrication, Tissue-Engineered Heart Valves

Apr. 3, 2007 Ali Khademhosseini, PhD; BWH, HMS

John Mayer, Jr., MD; HMS, CHB
• Microengineering the Cellular Environment through the Interplay between Microfabrication and Biomaterials

• Current Progress toward a Tissue Engineered Heart Valve
       
Biomaterials & Tissue Engineering News
ARTICLE TITLE PUBLICATION DATE
Creating the Body’s Microenvironment to Grow Artificial Organs National Defense Magazine Mar. 2008
BioEngine: One Step Closer to Artificial Liver Device XConomy Sep. 20, 2007
A Step Toward Tissue-Engineered Heart Structures for Children Science Daily Sep. 20, 2007
     
Video/Podcasts
 

Jeffrey Norenstein, PhDProgram Leaders

Jeffrey Borenstein, PhD
jborenstein@draper.com
Phone: 617-258-1686

CIMIT RESPONSIBILITIES
Co-Program Leader,
Biomaterials & Tissue Engineering

Joseph Vacanti, MD

Joseph P. Vacanti, MD
jvacanti@partners.org
Phone: 617-724-1725

CIMIT RESPONSIBILITIES
Co-Program Leader,
Biomaterials & Tissue Engineering

Related Links

Tissue Engineering Lab at MGH

 






Get Involved Support CIMIT's Mission Join Industry Liaison Program Apply for Grant Contact Us Contact the Webmaster Site Acknowledgements Copyright © 2008 CIMIT site map linking policy privacy