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CIMIT’s Optical Diagnostics Program seeks to make diagnosis efficient, effective, and non-invasive. Projects like Optical Coherence Tomography (OCT) and Optical Frequency Domain Imaging (OFDI) make it possible to identify precancerous lesions or arterial plaque at very early stages.
Current Funded Optical Diagnostics Projects |
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| PRINCIPAL INVESTIGATOR | INSTITUTION | PROJECT TITLE | |
| Jonathan Bernstein |
Draper Laboratory | Micro-Mirror Based 3D Endoscopy | |
| Charles Lin | Massachusetts General Hospital |
Label-free detection and quantification of circulating leukocytes by in vivo flow cytometry | |
| Dieter Manstein | Massachusetts General Hospital |
Non-invasive measurement of intraepidermal nerve density | |
| Jerome Mertz | Boston University | Hybrid-Illumination Fluorescence Macroscopy with Out-of-Focus Blur Rejection | |
| Christopher Thompson | Brigham and Women’s Hospital |
Endoscopic Transcolonic Survival Study | |
| Kirby Vosburgh | Massachusetts General Hospital |
Novel Image Registered Procedures | |
| George Washko | Brigham and Women’s Hospital |
Quantitative Analysis of Airways and Airspace Disease Visualized on Computed Tomographic Imaging in Subjects with COPD | |
| George Whitesides | Harvard Medical School |
Development of a Prototype Microfluidic
Detector Enabling CD4 T Cell Counting in HIV/AIDS |
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| Anna Yaroslavsky | Massachusetts General Hospital |
Wide-Field High-Resolution Imaging for the Detection of Nonmelanoma Skin Cancers | |
| Dvir Yelin | Massachusetts General Hospital |
Comprehensive Volumetric Confocal Microscopy via Spectral Encoding | |
| Seok Hyun Yun | Massachusetts General Hospital |
Brillouin Microscopy for Tissue Biomechanics
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| Seok Hyun Yun | Massachusetts General Hospital |
Novel ocular biomechanical analysis | |
Contact Haleh Armian, CIMIT Senior Manager, Business Development
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Recent Publications by CIMIT Investigators |
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| INVESTIGATOR/AUTHOR | PUBLICATION | ARTICLE | DATE |
| Akkin, T., Joo, C., de Boer, J. F. | Biophys J. 15:93(4):1347-53 |
Depth-resolved Measurement of Transient Structural Changes During Action Potential Propagation |
2007 |
| Boverman, G., Fang, Q., Carp., S. A., Miller, E. L., Brooks, D. H., Selb, J. Moore, R. H., Kopans, D. B., Boas, D. A. |
Phys Med Biol. 52(12):3618-41 |
Spatio-temporal Imaging fo the
Hemoglobin in the Compressed
Breast with Diffuse Optical Tomography |
2007 |
| Chia, S., Christopher Raffel, O., Takano, M., Tearney, G. J., Bouma, B. E., Jang, I. K. | Coron Artery Dis 18(6):423-7 |
In-vivo Comparison of Coronary
Plaque Characteristics Using Optical Coherence Tomography in Women vs. Men with Acute Coronary Syndrome |
2007 |
| Desjardins, A. E., Vakoc, B. J., Tearney, G. J., Bouma, B. E. | Opt Lett 32(21):3158- 60 |
Backscattering Spectroscopic Contrast with Angle-Resolved Optical Coherence Tomography | 2007 |
| Evans, J. A., Bouma, B. E.,
Bressner, J. Shishkov, M.,
Lauwers, G. Y., Mino-Kenudson, M., Nikshioka, N. S., Tearney, G. J. |
Gastrointest Endosc 65(1):50-6 |
Identifying Intestincal Metaplasia
at the Squamocolumnar Junction by Using Optical Coherence Tomography |
2007 |
| Frangioni, J. V., Kim, S. W., Ihnishi, S., Kim, S., Bawendi, M. G. |
Methods Mol Biol 374:147”60 |
Sentinel Lymph Node Mapping with Type-II Quantum Dots |
2007 |
| Joo. C., de Boer, J. F. | Opt Lett. 32(16):2426- 8 |
Spectral-Domain Optical Coherence Reflectometric Sensor for Highly Sensitive Molecular Detection | 2007 |
Optical Diagnostics at the CIMIT Forum and Past Events |
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| EVENT | DATE | SPEAKERS | DETAIL |
| Lester Wolfe Workshop in Laser Biomedicine: Shining Light on Melanoma |
April 22, 2008 | Arthur J. Sober, MD: MGH Lihong Wang, PhD: Zeina Tannous, MD: MGH Mark F. Naylor, MD: University of Oklahoma |
Framing the Problem of Melanoma Diagnosis Photoacoustic Tomography and Melanoma Imaging
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| Forum: New Views of Inside the Body: Optical Imaging for Biomedical Applications | Feb. 19, 2008 | Gary Tearney, MD, MGH, CIMIT Seok-Hyun (Andy) Yun, PhD, MGH |
Seeing Inside: Optical Frequency Domain Imaging and Endo-Microscopy and Biomechanical Engineering: |
| Lester Wolfe Workshop: Laser Biomedicine: Frontiers in Modern Microscopy |
Nov. 20, 2007 |
Tony Wilson; Oxford University Wonshik Choi; MIT Carolyn Larabell; UC San Francisco, Lawrence Berkeley National Lab Xiaowei Zhuang; Harvard, Howard Hughes Medical Institute Johannes de Boer; MGH Katrin Willig; Max Planck Institute for Biophysical Chemistry Katrin Kniepp; Harvard, MGH |
•Making Light Work in Microscopy •Field-based Tomographic Microscopy •Imaging Cellular Structures and Molecules with X-ray Tomography •Super-Resolution Optical Microscopy with STORM •3D Optical Coherence Phase Microscopy •STED Microscopy •Nonlinear Microscopy in Local Optical Fields |
| Forum: The Future of Optical Medicine |
May 29, 2007 |
Irving Bagio, PhD; BU Sergio Fantini, PhD; Tufts Guillermo Tearney, MD, PhD; MGH David Benaron, MD; Stanford; CEO, Spectros Corp. Satish Singh, MD; BU |
•The Future of Optical Medicine |
| Lester Wolfe Workshop: Experts on Breast Cancer |
Apr. 17, 2007 |
Barbara L. Smith; MD, PhD; MGH,
HMS Maryann Fitzmaurice, MD, PhD; Case Western Reserve Arjun Yodh, PhD; U. of Pennsylvania Stephen Boppart, MD, PhD; U. of Illinois, Mills Breast Cancer Institute |
•Optical Methods in Breast Cancer |
Optical Diagnostics In the News |
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| ARTICLE TITLE | PUBLICATION | DATE |
| Endoscopic imaging | Channel 7 News Healthcast | Jun. 24, 2008 |
Video:
CIMIT Life-Saving Innovation
in Early Stage of Trauma. |
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